RE:RE:Roche's I/O TIGIT + Tecentriq combo effective .. BUT ...Safety data wasn't clean, as there were two grade 5 events—which in trial speak means deaths—from the combo arm of the trial according to detailed data presented at the European Society for Medical Oncology Immuno-Oncology virtual congress in December 2021. The two treatment-related deaths were the results of pyrexia—or fever—and infection.