RE:NeutropeniaMetals Neutropenia can be a side effect of immunosuppressive drugs but there are also many other ways it can manifest. Also you have to take into account that the liver is front line immune tissue and will require more immunosuppression in the first place. Vertex considered it not related to VX-880 but from the FDA's perspective it's on hold if they thought it was just one patient's reaction to immunosuppression they would allow for dose escalation in the other patients.