RE:RE:RE:New paper on MTf-pep I should have more clearly stated the difference between liver-produced LSD enzymes and the xB3 enzymes that Bioasis can manufacture.
Bioasis xB3 drugs are generally understood to be produced as fusion proteins by genetically programmed mammalian cell lines, as WuXi does, or maybe other methods such as Protalix's ProCellEx plant cell manufacturing system. Either way, the drug is expressed by the cells, harvested, tweaked, processed and put in containers ready to be injected into patients.
The method in this new paper causes the liver to produce the drugs so that no enzyme injections are required. There may be periodic gene therapy injections to keep liver production at required levels, but basically, this method causes the patient's own body to produce the required enzyme, and that enzyme, because the peptide forms a part of it, can cross the BBB, thereby eliminating enzyme replacement therapy.
jd