RE:Big Pharma is facing a looming $236 Billion patent cliff
The patents will for sure be interesting as ONC has itself lost 100 patents in the last 5 years and it looks like 60 in just the last 2 months if you compare the investor presentations.
Also Matt Coffey is quoted as saying in a recent conference "We just need the patents to be there at the time we apply for liscensee" which does make me a bit nervous as even though we have composition of matter patent till 2028 (extendable to 2033 but under what circumstances is it extendable and why not just extend it now), they need to have a successful trial and product approval at the time of application so the pace of a registration trial would for sure have to be faster than the current trials. Also how many of the other patents will be lose between now and a phase 3 registration trial.