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ProMIS Neurosciences Inc PMN

ProMIS Neurosciences Inc. is a development stage biotechnology company. The Company is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA), an alpha-synucleinopathy. Its proprietary target discovery engine applies a thermodynamic, computational discovery platform - ProMIS and Collective Coordinates - to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product portfolio includes PMN310 / Amyloid-beta, PMN267 / TDP-43, and PMN442 / Alpha-synuclein. The Company plans to investigate additional synucleinopathies, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Its wholly owned subsidiary is ProMIS Neurosciences (US) Inc.


NDAQ:PMN - Post by User

Post by M101on Jun 17, 2022 1:59pm
278 Views
Post# 34765226

acu193 question

acu193 questionI think I opined last year that the acu193 story had a hole in it for Promis investors: it entirely ignores the role of misfolding.  This seems relevant now that their stock price is down huge, but I'm not sure there's actually a connection as their P1 schedule has been pushed back.

So the question is, am I mssing something with Acumen or is their hypothesis simply that all ABOs are bad, so while some mers are worse than others it's safe tp target them all?   I feel like I must have it wrong because that logic doesn't explain AD progression, leaving it to cascade effects with presumably other individually variable triggers. 

With Promis and Acumen now on very similar time lines through P1 the market will be looking for differentiation, but neither company will whizz on the other's parade so what will be the strategy? .  
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