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ProMIS Neurosciences Inc PMN

ProMIS Neurosciences Inc. is a clinical-stage biotechnology company. It is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). Its proprietary target discovery engine applies a thermodynamic, computational discovery platform-ProMIS and Collective Coordinates-to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product candidates are PMN310, PMN267, and PMN442. The PMN310 is a monoclonal antibody designed to treat AD by selectively targeting toxic, misfolded oligomers of amyloid-beta. PMN267 product candidate targeting ALS. PMN442 is a drug candidate being developed for MSA designed to selectively target and protect against pathogenic a-syn species.


NDAQ:PMN - Post by User

Post by retiredcopon Jun 23, 2022 4:08pm
153 Views
Post# 34778414

Biogen losing traction

Biogen losing traction  For Biogen’s ill-fated Alzheimer’s disease drug Aduhelm, a narrow Medicare reimbursement policy is taking a toll beyond sales and on the company’s clinical development plan.

Biogen has pulled the plug on the observational ICARE AD trial, which was meant to collect real-world data on Aduhelm’s use in the U.S., according to an update posted Tuesday on ClinicalTrials.gov. A Biogen spokesperson confirmed the status to Fierce Pharma.

The termination comes as a result of the national coverage policy, Biogen said on the clinical trial registry. “t is expected there will be limited [Aduhelm] prescription and usage in routine clinical practice, making the study not feasible for enrollment.”

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