Couple of studies GH/IGF-1 axis is associated with intrahepatic lipid content and hepatocellular damage in overweight/obesity
“Higher peak-stimulated GH was also associated with lower ALT. Higher IGF-1 was associated with lower risk of liver fibrosis by Fibrosis-4 scores.
Individuals with NAFLD have lower peak-stimulated GH but similar IGF-1 levels versus controls. Higher peak-stimulated GH is associated with lower IHL and less hepatocellular damage. Higher IGF-1 is associated with more favorable fibrosis risk scores. These data implicate GH and IGF-1 as potential disease modifiers in the development and progression of NAFLD.”
So there are concluding higher IGF-1 levels will result in lower fibrosis by fibrosis-4 score.
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciac337/6577095?redirectedFrom=PDF
The FibroScan–aspartate aminotransferase (FAST) score was developed to identify patients who have histologic NASH with high nonalcoholic fatty liver disease activity score (NAS ≥4) and significant liver fibrosis (≥F2), which has been associated with higher risk of end-stage liver disease.
“On multivariable analysis, HIV infection was associated with 3.7-fold higher odds of elevated FAST score (P = .002), and greater waist circumference (per 10cm) was associated with 1.7-fold higher odds (P < .001).
Our findings suggest that HIV is an independent risk factor for NASH with significant activity and fibrosis.”
Again HIV seems to increase not only NAS score but also the fibrosis and we know Tesamorelin was only tried in PLWH.
I have sent both studies to Christian. I don’t have access to the full articles!