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ProMIS Neurosciences Inc PMN

Healthcare Biotechnology
ProMIS Neurosciences Inc. is a clinical-stage biotechnology company. It is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). Its proprietary target discovery engine applies a thermodynamic, computational discovery platform-ProMIS and Collective Coordinates-to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product candidates are PMN310, PMN267, and PMN442. The PMN310 is a monoclonal antibody designed to treat AD by selectively targeting toxic, misfolded oligomers of amyloid-beta. PMN267 product candidate targeting ALS. PMN442 is a drug candidate being developed for MSA designed to selectively target and protect against pathogenic a-syn species.


NDAQ:PMN - Post by User

ProMIS Neurosciences Inc > Management and the future
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Comment by M101on Jul 14, 2022 1:33pm
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Post# 34824679

RE:RE:RE:RE:Management and the future

RE:RE:RE:RE:Management and the future
Yes, the lack of partnering is an issue. M&A not so much since no one is going to shell out $1B+ for a company with no human trial results in a field where rats have been unreliable.

But I've yet to discover any big pharma player touting its cutting edge research into protein misfolding. The CNS field has been dominated by players exploring natural drugs, or their modified variants, which were "serendipitously" discovered to offer some symptomatic benefit to some population.  These things have momentum, internal politics determine the pace of change and Promis has yet to post any eye-popping results.
 
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