RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:The listA biopsy is done on every patient. They did a biopsy on my wife. It is for research purposes but not for screening inclusion. They try their best to pick a tumor that is easiest to get to. If nothing is easily accessible then archival tissue is accepted.
jfm1330 wrote: Turn it the way you want, not directly testing patients for sortilin expression is clearly a subpar way to do this trial. Again, overexpression is relative, with the exact data about overexpression they would better understand what is going on and the relation with efficacy and they would not treat patient for nothing.
I understand this is early and that biopsy in most cases is painful for patients ans can involve some risks of internal hemorrhage. I know it, I got one from the liver and you need to lay down on a bed, not moving, for three hours to be sure it will not bleed inside your body. So I understand all they want is to treat patient with good odds of overexpressing sortilin, but they will have to do things differently in phase II and beyond.