RE:RE:A few answers on IMMU Yes, they have been testing it for other indications and that was the basis on which Gilead snapped it up. I am guessing here, but at the time of the $21bil acquisition I recall there were a fair number of both mono therapy trials and combo trials they had started and they were in various phases at the time of the takeover. I believe the furthest along was for a new indication (other than metastatic TNBC) and the phase 2 readout was not that impressive compared to SOC therapies for that cancer. I think one of the combo trials was also on the "meh" side. But there are still a bunch of trials going on with the IMMU drugs Gilead bought.
I don't think I have ever heard THTX say they will immediately stop the basket trial or getting a comprehensive data set on the basket trial. They've only stated that if one tumor sees a strong data set around safety and efficacy, they will design a P2 and get FDA sign off and start going on it. From what I can see, it would be common to have a few trials going providing you see the efficacy. At that point you could easily trigger the ATM or raise capital to fund what are quite small and short trials, so why wouldn't you? Further, if you see a decent number with some level of efficacy, maybe you can add the "for all solid tumors over expressing Sort1 that are advanced and refractory, or metasticizing" . That is Christian's Holy Grail if he can get it there.
jfm1330 wrote: Don't forget that we have a smal basket trial in the basket trial. They will try it on many other cancer types. For example, in their previous corporate presentions they had neuroendocrine cancers listed as cancer type that could overexpress sortilin. this cancer is not a main basket with many patients, but they could enroll a couple of them in the basket in the basket part. By the way, since you did research on IMMU, do you know what their efficacy results were in other cancer types results. Maybe I am too optimistic, but I think they will have good enough results to justify a phase II in more than one indication.
Wino115 wrote: They seemed to focus pretty quickly on TNBC from their basket trial as the data pointed to OK response rates and efficacy. Their basket trial looks fairly similar to THTX but was spread even wider amongst tumor types.