ScienceFirst wrote: June 1, 2022 — Monkeypox virus is a Tier I (enveloped virus); thus, when disinfectants damage their lipid envelope, the virus is no longer infectious. August 19, 2020:
Theralase Signs Agreement with University of Manitoba to Commence Development of Coronavirus Vaccine and Therapy November 13, 2020:
Theralase Technology Demonstrates High Kill Rate of Coronavirus (BSL-2) – Theralase Technologies Theralase previously reported that the Company’s PDC technology was effective in the destruction of Influenza H1N1 and Zika viruses at low nanomolar concentrations. These studies were expanded to include coronavirus (BSL-2). As a note, COVID-19 is caused by coronavirus (BSL-3), not coronavirus (BSL-2). An assay was established to measure coronavirus destruction and using this new assay the Theralase® PDC technology was able to destroy coronavirus (BSL-2) with drug doses 5 times lower than what was used to kill Influenza H1N1 and Zika viruses. These drug doses demonstrated a 99.995% destruction rate of the BSL-2 coronavirus and are significantly lower than those used by the Company to treat cancers; hence safe for human use. All coronaviruses are considered similar in their structure and these new results strongly suggest that Theralase®’s PDC will be highly effective against the SARS-CoV-2 (coronavirus (BSL-3)) virus responsible for COVID-19.
Dr. Kevin Coombs, Ph.D., Professor, Department of Medical Microbiology, who is the principal investigator for the Theralase® PDC destruction of coronavirus (BSL-2) stated “The Theralase® compound is extremely effective in the destruction of this virus. I strongly believe that it will be equally effective against the SARS-CoV-2 (coronavirus (BSL-3)), responsible for the current COVID-19 pandemic. This lays the ground work for an effective COVID-19 vaccine using Theralase®’s patented PDC technology. Further studies are underway to determine the Mechanism Of Action (“MOA”). I look forward to continue working with Dr. Arkady Mandel and the Theralase team in the development of this exciting technology”.
Dr. Arkady Mandel, M.D. Ph.D., DSc Chief Scientific Officer, Theralase Technologies Inc. stated, “We are excited that the two stages of our research, and development of a COVID-19 vaccine have been successful; specifically: the destruction of lipid enveloped Influenza H1N1 and Zika viruses followed by the destruction of the coronavirus (BSL-2) virus with Theralase®’s patented PDC. We look forward to expanding this research and development to SARS-CoV-2 (coronavirus (BSL-3)), responsible for the current COVID-19 pandemic, in the development of a safe and effective vaccine in the not too distant future.”
April 9, 2021:
Theralase Commences Collaborative Research with National Microbiology Laboratory for Development of Coronavirus Vaccine PHAC is a world leader in vaccine creation and has a long history of vaccine development. PHAC scientists developed the world’s first approved Ebola vaccine (Ervebo), which the Government of Canada donated to the World Health Organization (“WHO”) during the height of the 2014-16 Ebola outbreak and in the process helped to save countless lives in Africa.
Darwyn Kobasa, Ph.D., Head, High Containment Respiratory Virus Group, Special Pathogens, PHAC/NML, stated “Our research expertise will help assist Theralase® to research and develop an effective COVID-19 vaccine that is robust enough to vaccinate against the main phenotype of the disease and its emerging variants. NML has unique capacity to conduct preclinical research in animal models, that must occur in high containment laboratory space, which is essential to the development of an effective COVID-19 vaccine. I am delighted for having the opportunity of testing the Theralase® anti-viral platform technology at PHAC. The in-vitro data I have reviewed demonstrates that Theralase®’s PDCs have a very high log kill of various Biological Safety Laboratory (“BSL”)-2 viruses at nanomolar concentrations. The focus of our CRA is to demonstrate these same results using the SARS-CoV-2 virus, which is a BSL-3 virus. The tested efficacy in BSL-2 virus destruction, reported by Dr. Kevin Coombs of the University of Manitoba, shows that the Theralase® PDC is comparable to, or better than, many other anti-virals that my lab has tested. I look forward to working with Dr. Arkady Mandel and the Theralase® team in the development of this exciting technology.”
Feb. 07, 2022:
Theralase Demonstrates Proof-of-Concept for Canadian-Made COVID-19 Vaccine Darwyn Kobasa, Ph.D., Head, High Containment Respiratory Virus Group, Special Pathogens, PHAC, stated “My team’s initial results indicate that, when activated by light, TLD-1433 is very effective in inactivating the COVID-19 virus at low concentrations, thus demonstrating proof-of-concept in the development of a Canadian-made COVID-19 vaccine.”
Kevin Coombs, Ph.D., Professor, Department of Medical Microbiology at UM, stated, “The work conducted at my lab and the work conducted by PHAC’s National Microbiology Laboratory, has demonstrated that a large range of enveloped viruses can be successfully inactivated by light-activated TLD-1433 at low concentrations. I am delighted that Theralase®’s and my initial preclinical research has proven to be effective in COVID-19.
Dr. Arkady Mandel, M.D., Ph.D., D.Sc., Interim Chief Executive Officer and Chief Scientific Officer, Theralase® stated, “The latest preliminary results by Dr. Kobasa and Dr. Coombs, demonstrates that the Theralase® vaccine may potentially be effective as a Canadian-made wholly-inactivated vaccine to prevent individuals from contracting COVID-19 in the future and warrants further research to confirm the findings. The research also demonstrates that the Theralase® platform is extremely versatile, with an ability to be applicable to a wide range of enveloped viruses. This would allow the Company to tailor the vaccine to be potentially effective against contracting various viruses (existing and/or new) and their associated variants. Based on this encouraging data, the Company intends to move forward in the research, development and commercialization of the Theralase® COVID-19 vaccine, subject to the required regulatory approval.”