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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Comment by Noteableon Aug 06, 2022 3:04pm
215 Views
Post# 34876506

RE:RE:RE:RE:RE:RE:RE:PwC sees continuation of US$ 5 to 15 Billion Bio M&A Deals

RE:RE:RE:RE:RE:RE:RE:PwC sees continuation of US$ 5 to 15 Billion Bio M&A DealsThe global sales for migraine drugs have been valued at $4.6 billion in 2020 with a CAGR of more than 9%. The new classes of drugs that are in late-stage pipeline and have higher clinical efficacy, such as the introduction of calcitonin gene-related peptide (CGRP) monoclonal antibodies that have been the focus for Biohaven, are also driving the market growth which could reach USD$11 Billion by 2029. CGRP-targeted drugs, could account for more than $6.5 billion of sales in 2027.

Now compare the projected global market size to the cancer market. The global cancer therapeutics market size is projected to reach around US$ 335.06 billion by 2029. The cancer market is expected to be approximately 30x greater than the size of the global migraine market. 

Meanwhile 
PD-1/PD-L1 checkpoint inhibitors have been significantly outperforming the global oncology market, growing at 5-year CAGR of 45%, or three times the rate of oncology overall, and are expected to reach $58 billion globally by 2025. The important fact accompanying the USD$ 58 Billion projection is that this value only considers the PD-1/PD-L1 checkpoint inhibitors used as a monotherapy and therefore effective in only 15-20% of the patients used. Combination with ONCY pelareorep is anticipated to increase the effectiveness of these checkpoint inhibitors by 2-3X thereby increasing the above expectation to between USD$ 116 Billion to USD$ 168 Billion by 2029, thus increasing the overall cancer therapeutics market size to around USD$ 503 Billion (335b+168b) by 2029 instead of the above projected USD $335.06 Billion figure.  

This notwithstanding Pfizer announced the acquisition of Biohaven for USD$11.6 Billion ... so I would suggest that ONCY's acquisition value would fall into the USD$ 8 to USD$15 Billion range quite nicely 
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