RE:RE:RE:RE:Another solid quarterBy combining PGX-YBG with PGX-Alginate, for instance, to get PGX-YBG-Alginate, CZO could also combine the delivery capabilities of both PGX-YBG and PGX-Alginate into a single treatment. CZO's recent alginate-CoQ10 news release pointed to the possibility of additional potent delivery systems.
"While PGX-processed alginate is poised to become a key commercial strategic asset for the Company along with beta glucan from yeast, findings of this study could lead to the development of many other more potent delivery systems enabling Ceapro to expand into a high-end Life Science company,” said Gilles Gagnon, M.Sc., MBA, President and CEO." news release Ciao wrote: From the link and the significance of macrophages:
Another Trojan horse, not yet in clinical trials but steadily gaining more attention as potential delivery vehicles, are macrophages. The inherent homing capabilities of these immune cells to reach damaged, infected or malignant tissue, make them perfect candidates for the directed delivery of drugs in small concentrations, which could lower the risk of drug-associated adverse effects even further. Many approaches of macrophage-mediated therapeutic delivery focus on drug-loaded nanoparticles, but the delivery of anti-cancer viruses and antisense oligonucleotides is currently also under investigation. Due to their phagocytic properties, the loading into macrophages can (in most cases) easily be achieved by incubation and can be modulated by changing the shape, size, or surface property of the cargo; however, a variety of other obstacles need to be overcome. The challenges of using macrophages as carriers are the toxicity of the drug to the carrier cells, impairment of macrophage functions (e.g. reaction to chemotactic stimuli), the achievement of a controlled therapeutics release and, most importantly, maintenance of cargo integrity. Even though there are a lot of promising ideas to address some of the problems, for instance by copying tricks microbes developed to survive within, kill or even use macrophages, there still seems to be a long way for the Trojan macrophage to reach the clinic.