RE:RE:RE:RE:RE:RE:“Low dose docetaxel”I don't know how often I will have to repeat it, it is not clear what this 11% of free docetaxel value they published mean. Is it AUC (area under the curve) which qhantifies the total docetaxel released in the blood stream over time or is it Cmax, which is maximum concentration of docetaxel reached in the bloodstream after injection. If it's AUC, it is unlikely that it would generate efficacy, if it's Cmax, then it would be another story. Again. Even if the concept would not work, i.e: TH1902 is not entering inside sortilin expressing cells or any other cells, it would still act as a slow release system for docetaxel with slow enzymatic cleavage of the linker by enzymes called esterases (able to cleave ester bonds, which is the nature of the chemical bond between the linker and docetaxel). So they really need to give clarity on that aspect and stop publishing vague stuff as if only scientific illiterates were reading them.
Wino115 wrote: Clearly not 11% free dox floating around did that.