RE:RE:RE:Grail even less accurate than previously thoughtLithLover wrote: Glad you asked Here are the published results:
Grail in
Annals of Oncology: https://www.annalsofoncology.org/article/S0923-7534(21)02046-9/fulltext
Overall sensitivity for cancer signal detection was 51.5% (49.6% to 53.3%); sensitivity increased with stage [stage I: 16.8% (14.5% to 19.5%), stage II: 40.4% (36.8% to 44.1%), stage III: 77.0% (73.4% to 80.3%), stage IV: 90.1% (87.5% to 92.2%)]. Stage I-III sensitivity was 67.6% (64.4% to 70.6%) in 12 pre-specified cancers that account for approximately two-thirds of annual USA cancer deaths and was 40.7% (38.7% to 42.9%) in all cancers. Aristotle in
Journal of Clinical Oncology https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.15_suppl.e15037
Aristotle classified cancer profiles with sensitivities from 55.6-100% and positive predictive values from 5.6-77.7% at a specificity of 99.0% (Table). Liked2Think wrote: LithLover wrote: Grail test found to have even more false positives than before. Imagine taking the test being told you have cancer and than finding out the test was only 38% accurate.
29.8% of the participants with false alarms underwent invasive procedures Sept 12, 2022
https://www.medtechdive.com/news/amid-merger-turmoil-illuminas-grail-unit-reports-downturn-in-accuracy-of/631583/
- Updated data on Grail’s multi-cancer early detection blood test Galleri suggest the diagnostic is less accurate than previously thought.
- Last year, Grail reported that 44.6% of patients with positive test results actually had cancer. In the latest analysis, the figure, known as the positive predictive value, has fallen to 38.0%.
- News of the falling predictive power seen in the study, which used an old version of Galleri, comes amid growing doubts about the fate of the Illumina-Grail merger, which the European Commission has blocked.
Has there ever been any 3rd party verification that the Aristotle test is any better or is that just another thing investors should just believe from a ceo that hasn't been able to keep his word multiple times in the past?
How many of Stage's patients that have been diagnoised with cancer through aristotle actually had cancer? Is there any real world data at all?
Aristotle classified cancer profiles with sensitivities from 55.6-100% What were the numbers betwen the two vastly different percentages? Is a 55.6% great? Yes better than 38% and maybe the numbers overall were closer to 100% but whats the actual numbers?
No one in this space seems to have the ability to track the simpliest of things.