RE:RE:RE:Recent studyI gave a reference a few weeks ago pointing to high sortilin expression in high grade prostate cancers in comparison with low grade tumors of the same cancer. This is in the first paragraph of the discussion section. It seems to confirm that some high grade prostate cancers can be very good if TH1902 really works as described.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884004/
In addition, the level of NTSR3/sortilin in high-grade gliomas and aggressive prostate cancers was higher than those in normal and low-grade (or indolent) tumor tissues jfm1330 wrote: Another reference confirms that sortilin is overexpressed and involved in neuroendocrine tumors and metastasis of these tumors. Good for me to read that, hope for the future. Imagine being saved at some point in time y the company I was invested in. It would be an amazing story.
The article also confirms overexpression of sortilin in aggressive prostate cancers, which is good for us to know considering the results of phase Ia. This article also confirms what I was talking about the other day, sortilin is found in the membranes of the Golgi apparatus and the endoplasmic reticulum, which could explain why through endosome internalization TH1902 can bypass efflux pump. Also, Golgi and ER are involved with tubulin, the protein that docetaxel is interacting with.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884004/
Wino115 wrote: Great find. Ours boys research is mentioned twice - footnotes 38 and 88. Getting some recognition for the PDC and sort1 target!