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Oncolytics Biotech Inc ONCY


Primary Symbol: T.ONC

Oncolytics Biotech Inc. is a biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to phase 3 licensure-enabling studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Comment by Capitalistaon Nov 10, 2022 10:29am
178 Views
Post# 35088285

RE:RE:ONCY Goblet-1 trial pancreatic trial -> COMPLETE RESPONSE !

RE:RE:ONCY Goblet-1 trial pancreatic trial -> COMPLETE RESPONSE !"Coffey compared the treatment’s mechanism of action to a common movie trope - a bank robbery. He painted a scene in which an anonymous robber runs into the bank, slips the teller a note to give him the money and runs out of the bank. When he opens the bag, what comes out is an explosion of purple dye.

“We’re purple dye,” Coffey said. “We take an anonymous tumor that's been growing and festering that your immune system hasn't detected as being a problem. We selectively infect it with a virus. And now, your immune system can detect that there's something wrong with the cell.” 

After that, he said, natural killer cells rush into the tumor and eliminate the infected cells. The patient’s body then forms an adaptive immune response against the tumor, and according to patient samples, this turns into long-term immunity. "

The above is from the biospace.com article referenced by Noteable.  The action described by MC is pretty much identical to that of a vaccine.  Given Pela's proven safety numbers, it might be interesting to test Pela by itself on a large sample of healthy people to see if there is any benefit obtained - i.e. not developing cancer in the first place.  The general population (existing cancer incidence stats) could be the control, or a specific control group could be used. 

 

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