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Oncolytics Biotech Inc ONCY


Primary Symbol: T.ONC

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > 12/13 Goblet PC patients had Stage IV metastatic (M1) cancer
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Comment by Noteableon Nov 13, 2022 1:20pm
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Post# 35094970

RE:12/13 Goblet PC patients had Stage IV metastatic (M1) cancer

RE:12/13 Goblet PC patients had Stage IV metastatic (M1) cancer

Objective response rate (ORR) and clinical benefit rate (CBR) in GOBLET's PDAC cohort (n=13) were 69% and 85%, respectively, as of the SITC poster's data cutoff date (October 12, 2022). Additional data and conclusions presented in the poster are summarized below.

 
  • One of thirteen evaluable patients achieved a confirmed CR
  • Eight of thirteen evaluable patients achieved a PR
  • Two of thirteen evaluable patients achieved stable disease (SD)
  • The observed ORR of 69% is substantially higher than the average ORR of ~25% reported in historical control trials of gemcitabine and nab-paclitaxel in pancreatic cancer1-4
  • GOBLET's PDAC cohort exceeded the protocol-specified success criterion for Stage 1 of ≥ 3/12 objective responses
  • The studied treatment combination has been well tolerated, with no safety concerns identified to date

https://www.streetinsider.com/Corporate+News/Oncolytics+Biotech+%28ONCY%29+Presents+Strong+Updated+Clinical+Data+from+Phase+12+GOBLET+Trial/20829707.html
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