RE:RE:RE:RE:RE:RE:CellPress: Emerging Field of OV Based Cancer ImmunotherapyMore specifically, HIF-1α is related to other variables with a more consolidated predictive and prognostic value on outcome and all these variables are associated with a more aggressive and hypoxic tumor microenvironment.
ONCY's oncolytic virus pelareorep (reovirus) is able to down-regulate HIF-1α signalling and by doing so is able to convert an otherwise aggressive and hypoxic tumor microenvironment (TME) into one that can promote T cell function, and is conducive for immune checkpoint inhibition, as the AWARE-1 study is demonstrating.