ONCY's pelareorep involves direct dendritic cell activation
Reovirus is a multipotent immune agent with oncolytic properties that has demonstrated clinical efficacy in early phase trials in metastatic KRAS mutant colorectal cancer. Its mechanisms of anti-tumor action involve direct dendritic cell activation, by production of proinflammatory cytokines, dendritic cell mediated NK cell activation, which lead to exocytosis of perforin/granzyme and Fas-associated death domain, and activation of T-cells.
- So Yeon Kim1 , Radhashree Maitra2 , Sanjay Goel1,
1Montefiore Medical Center, 1695 Eastchester Road, Bronx, New York 10461, USA; 2Department of Biology, Yeshiva University, 500 West 185th Street, New York 10033, USA; 3Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York
https://e-century.us/files/ajtr/13/12/ajtr0136713.pdf