RE:RE:RE:RE:RE:RE:ONCY's pelareorep activates interferon (IFN) signallingONCY's pelareorep activation of IFN-α signaling /pathways while simultaneously inducing the down regulation of HIF-1α expression resuls in particular "cross-talk" involved in the remodeling of a hypoxic TME while "priming" the TME for the addition of immune checkpoint inhibitors, and is leading to a rationale strategy in the development of new therapeutic interventions targeting TME-supplemented IFN signaling and HIF-1α programming (in tumor cells) to not only treat but prevent disease relapse after I/O treatment with pelareorep + I/O therapies.