RE:RE:RE:RE:RE:RE:RE:RE:RE:ONCY's pelareorep activates interferon (IFN) signallingCARs initiate robust T cell activation and subsequent cytolytic killing of the target cell through an intracelluar signaling domain.. Utilizing T cells expressing chimeric antigen receptors (CARs) to identify and attack solid tumors has proven challenging, in large part because of the lack of tumor-specific targets to direct CAR binding. Tumor selectivity is crucial because on-target, off-tumor activation of CAR T cells can result in a loss of efficacy and potentially lethal toxicities.
Along with what has been already posted regarding ONCY's pelareorep ability to down-regulate HIF-1alpha, coating CAR-T cells with pelareorep for intravenous administration results in pelareorep's further ability to present "pelareorep labeled" tumor-specific targets for direct CAR binding in solid tumors, thus avoiding off-target activation of CAR-T cells, increased treatmdnt efficacy and the avoidance of lethal toxciites that CAR-T cells have otherwise been known for.