RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:ONCY's pelareorep activates interferon (IFN) signalling
HIF is a direct transcriptional suppressor of interferon regulatory factors. As already discussed pelareorep is able to down-regulate the expression of the HIF genes and in so doing facilitates interferon (IFN) activation, as the AWARE-1 study reported on during SABCS 2022 earlier this month.
https://www.nature.com/articles/s41586-022-04585-5