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Antibe Therapeutics Inc(Pre-Merger) ATBPF

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.


GREY:ATBPF - Post by User

Comment by baggerx99on Jan 04, 2023 9:45pm
337 Views
Post# 35204063

RE:RE:RE:RE:Watch Dopesick on Disney Plus

RE:RE:RE:RE:Watch Dopesick on Disney PlusSome takeaways from webinar.....

Otena....transitioning to acute market, confidence that they won't see toxicity issue....eliminating duration issues, acute regiment of 5-6 days

targeting urgent need of rapid onset of pain relief in 60 minutes with better formulation

opportunity super strong pain killer

weekly phone calls from biotech wanting to merge

Never been in a lesser risk point, completely understand liver issues

Lots of runway for IP on all patents, longer the runway, bigger the reward
MrMugsy wrote: Exactly right Bagger ...

It takes a few listens to really get all the details.

One comment that Dan made that really got me thinking was ... lots of H2S learning over the past 3 years which adds to our understanding and intelectual property.

That comment may relate directly to the improved understanding of our drug, how it affect the liver - and - the move to amorphous OTENA ... but ... there's a lot more work being done in unrelated studies that just might show even greater superiority.

For example, studies like ... anit-inflammatory drugs may cause chronic pain in RA

and ...

studies like ... Opioids nearly double risk for venous thromboembolism vs. NSAIDs

also ...

investigations into ... Common anti-inflammatories my be ruining kids teeth


All seem to be playing into the hope that OTENA just might be better than other anti-inflammatory drugs.

If H2S is the body's manager of inflammation and if it provides cellular protection and cellular repair,  to what extent does H2S reverse some of these other unwanted effects ?

Time will tell if we truly are better and exactly how much better.


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