RE:RE:Feature article about Theralase on biotuesdays.com website
wildbird1 wrote:
It does seem that this Jan 3,2023 article was written as a reminder of what TLD-1433 is capable of doing.
Here are two exemples.
1) Mechanism Of Action.
2) Dr.Mandel said" Less than one gram of TLD-1433 per patient".
Mechanism Of Action.
In the article there is a schematic that explain "Mechanism Of Action".
TLD-1433 is absorbed by the Bladder cancer cells through transferin receptors, once absorbed TLD-1433 is activated by a laser light and kill only the cancer cells.
It does seem that TLD-1433 doesn't care if it is a Bladder, Lung,Breast, early or late stage cancer cell, as long as it is a cancer cell TLD-1433 will get inside the cancer cell and kill it, at the same time keep the healthy cells intact.
Naturally different cancer have different cause and only a proper trial on each cancer will prove the above.
Less than one gram per patient.
Dr.Mandel said" Less than a gram of TLD-1433 is required to provide a single study treatment per patients".
Why does it take such a small amount of TLD-1433 to treat a patient?
One possible answer(there are many) could be in this old 2017 PressRelease.
https://theralase.com/theralase-researcher-discovers-super-potent-anti-cancer-drugs/
TLT said " Dr.McFarland has discovered a new generation of PDCs, that are 10 billion time more potent in killing cancer cells, than other tested PDCs".
Dr.McFarland compound TLD-1433 is so powerful & potent that you need only a few molecules of TLD-1433 to enter a cancer cell and kill it(after light activation).
In the same article Dr.Mandel said "Hence , safely and effectively, destroying a greater quantity of cancer cells per single treatment.
The above could explain in part why TLT treatment need only 1-2 treatment to achieve CR(Complete Responce) versus +15 to 30 treatments for Merck BCG.
As soon as TLT will have signed a partnership with a large Pharma, this large Pharma & TLT will certainly pump big money$$$$ into multiple trials, to make good use of Dr.McFarland powerful TLD-1433 PDC on other cancer.
10 Billion thank's to Dr.McFarland.
If/when TLD-1433 proves successful, Big Pharma/medical centers will be incentivized to replace less effective, less cancer-specific & more toxic older generation photosensitizers (I.e. Photofrin, chlorin derivatives, ALA & others) with TLD-1433. In order to expedite commercial success via broader clinical use of our drug/ACT, perhaps there is also the opportunity to do a basket study/studies where our single drug (whether it be TLD-1433, Rutherrin, Osmium or some combo therapy) is tested against multiple cancers/indications...would be a potential win-win for all parties involved, especially for patients who don't have the luxury to wait for single-indication trials. I could also see medical providers using our ACT/drug (in lieu of Photofrin, etc.) for other/similar cancers...such off-label use is considered acceptable & can be an alternative option for more resistant/severe cases. All of the above imo.
If all goes well with this trial, I can see a fairly rapid ramp-up of our ACT in the oncology-solid tumor field. There is an extensive list of reputable PDT centers in the U.S. & they have no/little choice but to use an outdated/older generation PS like Photofrin. In addition to our trial sites, here is a list of some reputable centers in the U.S. that could adopt our more effective/patient-friendly PS.
Photodynamic Therapy Center of Roswell Park Cancer Institute
Buffalo, New York RPCI’s Photodynamic Therapy Center offers PDT for lung, gynecologic, esophageal, oral, skin, head and neck cancers, as well as Barrett’s esophagus and other precancerous conditions or lesions.
Mayo Clinic Hospital Rochester, Minnesota (plus 6 satellite clinics in FL, AR, MN) The Mayo Clinic offers PDT for lung cancer, esophageal cancer, Barrett’s esophagus, stomach cancer, bladder cancer and bile duct tumors.
Cancer Treatment Centers of America Boca Raton, Florida (new central office) CTCA offers PDT for lung cancer, esophageal cancer and inoperable bile duct tumors.
MD Anderson Cancer Center Houston, Texas PDT is offered as a treatment option for lung cancer and esophageal cancer.
Dana Farber Cancer Institute Boston, Massachusetts (at five different locations) Photodynamic therapy has been approved for the treatment of patients with non-small cell lung cancer (central or endobronchial), esophageal cancer, basal cell carcinoma, and precancerous skin conditions.
Duke Cancer Institute Durham, North Carolina At Duke Cancer Institute, PDT is currently being used to treat esophageal cancer, non-small cell lung cancers, mesothelioma, and some skin cancers.
Fox Chase Cancer Center Buckingham, Pennsylvania Fox Chase offers photodynamic therapy (PDT) for the treatment of lung cancer as well as for obstructing tumors of the esophagus, severe dysplasia with Barrett’s esophagus, and early, localized gastric carcinoma.
Huntsman Cancer Institute/University of Utah Health Care Salt Lake City, Utah PDT is offered at this hospital for the treatment of esophageal cancer and endobronchial tumors (central lung cancer, tumors located in the airways).
Penn Medicine Hospitals Philadelphia, Pennsylvania (including 5 Hospitals) PDT is offered at Penn Medicine hospitals for lung cancer, head and neck cancer, and gastrointestinal tumors such as esophageal and gastric tumors.
Boston Medical Center Boston, Massachusetts The Boston Medical Center is offering PDT for Barrett’s esophagus and as a palliative treatment for esophageal cancer.
Cleveland Clinic Cleveland, Ohio Cleveland Clinic offers PDT for Barrett’s esophagus, bile duct tumors, and bladder cancer.
UW Carbonne Cancer Center Madison, Wisconsin Photodynamic therapy is offered here for central lung cancer and esophageal cancer.
Lakewood Ranch Medical Center Bradenton, Florida PDT is used at this Center for the treatment and palliation of esophageal, pulmonary and bladder malignancies.
UC San Diego Health System San Diego, California PDT is used at this clinic for the treatment of endobronchial tumors (central lung cancer, tumors located in the airways).
Puget Sound Gastroenterology/Seattle Gastroenterology Associates Seattle, Washington It appears that Dr. Bohorfoush offers PDT for Barrett’s esophagus and possibly early-stage esophageal cancer and bile duct tumors.
San Diego Interventional Procedures & Complex Airway Center San Diego, California This Center may offer PDT for central lung cancer (endobronchial carcinoma).
Kaiser Gornick LLP San Francisco, California This clinic offers PDT for Mesothelioma.
Valley Hospital, Blumenthal Cancer Center Paramus, New Jersey This center offers PDT for Barrett’s Esophagus.
HCA West Florida Tampa, Florida (16 affiliated hospitals) This clinic appears to provide PDT for bladder cancer.
Virginia Mason Hospital Seattle, Washington PDT is provided at this clinic for Barrett’s Esophagus.
Well Pacific Cancer Foundation Bellevue, Washington This Center specializes in PDT for brain tumors.
Gastrointestinal Associates (GIA), P.C. Knoxville, Tennessee Dr. Bergein Overholt specializes in photodynamic treatment of Barrett’s Esophagus and possible early-stage esophageal cancer.
Children’s Hospital of Wisconsin Milwaukee, Wisconsin Dr. Harry T. Whelan specializes in the photodynamic treatment of brain tumors; he is currently overseeing a clinical trial of PDT for recurrent high-grade gliomas.
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland PDT is offered for central lung cancer (small endobronchial tumors), Barrett’s esophagus, esophageal cancer, and some skin cancers.
Moffitt Cancer Center Tampa, Florida This center offers PDT for esophageal cancer, central lung cancer (endobronchial tumors) and other tumors.
The Ohio State University Comprehensive Cancer Center Columbus, Ohio (2 hospitals, including James Cancer Hospital) Ohio State’s photodynamic program offers PDT for curative, palliative and combined modality treatments of lung cancer.
Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine St. Louis, Missouri This center offers PDT for central lung cancer (endobronchial tumors) and possibly some esophageal tumors.
University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan This center offers PDT for central lung cancer (endobronchial tumors) and esophageal cancer, as well as possibly other cancers.
Vanderbilt-Ingram Cancer Center Nashville, Tennessee This center offers PDT for central lung cancer (endobronchial tumors) and esophageal cancer.