biOasis Technologies Ord Shs BIOAF

Healthcare Biotechnology

Bioasis Technologies Inc. is a Canada-based biopharmaceutical company focused on research and development of technologies and products intended for the treatment of patients with nervous system, including central nervous system, diseases and disorders. The Company is engaged in the development of its xB 3 platform, which is a peptide-based technology, for the transport of therapeutic agents, in particular biological products, across the blood-brain barrier (BBB). It is focused on both orphan drug indications, including brain cancers, and rare genetic neurodegenerative diseases and neuroinflammatory conditions. The Company is also focused on its Epidermal Growth Factor (EGF) platform for treating rare and orphan neurodegenerative and neuroinflammatory disorders. EGF is a protein that stimulates cell growth and differentiation, notably for myelin producing cells. Its development programs include xB3-001: Brain Metastases, xB3-002: Glioblastoma and xB3-007: Neurodegenerative Disease.

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biOasis Technologies Ord Shs > Midatech's Glioblastoma Drug and xB3 Synergy:

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Comment by prophetoffactzon Jan 15, 2023 6:44pm

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Post# 35224536

RE:RE:RE:RE:RE:RE:RE:RE:Midatech's Glioblastoma Drug and xB3 Synergy:

Relative distribution may not be the best. The best biodistribution may be flooding a specific region of the brain as with CED on top of relative distribution in the targeted area as with xB3 and the avoidence of systemic toxicities over the lifetime of administration which can result with IV administration. If you are also worried about off-target effects CED may alow the least drug to be used as the drug is targeted to the site.

Boomskid wrote: Denali uses the Tf receptor, poof. Would you like a post about the relative distribution of Tf and LRP-1 receptors in the human brain?

Although you could look up my old post about that just as easily as I can.

Or maybe you can find some new literature on it.

jd