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Algernon Pharmaceuticals Inc. C.AGN

Alternate Symbol(s):  AGNPF

Algernon Pharmaceuticals Inc. is a clinical-stage drug development company. The Company is focused on developing repurposed therapeutic drugs in the areas of non-alcoholic steatohepatitis (NASH), a type of liver disease, chronic kidney disease (CKD), inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF) and chronic cough as well as advancing a stroke program using N, N-Dimethyltryptamine (DMT). The Company operates through two segments, which includes the development of repurposed therapeutic drugs in Canada and the facilitation of the Company’s lead drug candidates into off-label phase II clinical trials (humans) in Australia. The Company's pipeline includes NP-251 (Repirinast) and AP-188 (DMT). The Company, through its subsidiary, Algernon NeuroScience Inc., is developing AP-188 (DMT) as a potential treatment for stroke and traumatic brain injury (TBI) recovery. Its NP-251 is being developed as a potential treatment for kidney inflammation and fibrosis.


CSE:AGN - Post by User

Post by Justdosomeddon Jan 18, 2023 1:42pm
95 Views
Post# 35231079

First Company to Begin Trials for DMT on Stroke

First Company to Begin Trials for DMT on Stroke
Phase 1 of the DMT stroke study has just begun, with the first patient being dosed yesterday. The first part of the study will use a single-escalating dose design aimed at identifying a safe and tolerable dose that will not produce psychedelic effects, in which they will then focus on seeing the effects of DMT to support the recovery of stroke victims. With the stroke management market worth above $30B, why DMT?
 
- DMT is an agonist of multiple receptors, including sigma-1 receptor. It is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotection, neuroplasticity, and neuroimmunomodulation (basically promotes brain health and recovery).
- DMT also aids in releasing Brain-Derived Neurotrophic Factor, a protein that helps in stroke recovery.
- DMT is an already established and safe drug, so I’m sure that there will be no problems with the safety side of things as they continue to look into the effects on stroke patients.
 
https://youtu.be/BfjAjt1jxuU
 
With $AGN.C continuing to explore the uses of drug repurposing, there’s a ton of potential considering some of their other research on IPF and chronic cough, of which they have already received an FDA orphan designation. Overall, considering the current $5M valuation, this could become extremely interesting as with pharmaceutical companies, once approval is given, there’s so much upside potential.
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