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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. It blocks viral entry into host cells while preserving normal immunologic function. The Company is also investigating an intramuscular method of administration of Trogarzo. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy.


TSX:TH - Post by User

Comment by qwerty22on Feb 16, 2023 11:01am
49 Views
Post# 35289867

RE:RE:RE:RE:RE:New Press Release - Theratechnologies Announces Path to Resume TH1902 Clinical Development

RE:RE:RE:RE:RE:New Press Release - Theratechnologies Announces Path to Resume TH1902 Clinical DevelopmentI think I have lower expectations than others about what is achievable in the lab and with a SAC. I think it's most likely they won't come up with anything more than hypotheses about what went wrong. They should be able to rule out certain possibilities but being able to put their finger clearly on what caused the first trial to fail seems unlikely to me. In that scenario the only way to go further is to test the best hypothesis in the clinic by recruiting more patients. I can't see a partner stumping up money to test hypotheses so if they want the program to move forward they'll need to pay to recruit more patients at least in the first instance. As you say that might not be a viable financial option atm if their priority is to get cash positive.

To put it another way. You are trying to jump from a failed path to a successful path. I can't see that leap happening only with data from the lab and input from a SAC, my expectation is it will need more clinical data too. I don't see a partner paying to help make the leap. They'll only come in if the leap is successful so THTX will have to take on the risk of the leap themselves.

We shouldn't rule out that the SAC and the lab work is just due diligence before closing down the program. They've invested a lot in the SORT1 program. tThey have to show they've thoroughly thought through they next decision, that would include the decision to park the program.
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