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biOasis Technologies Ord Shs BIOAF


Primary Symbol: V.BTI.H

Bioasis Technologies Inc. is a Canada-based biopharmaceutical company focused on research and development of technologies and products intended for the treatment of patients with nervous system, including central nervous system, diseases and disorders. The Company is engaged in the development of its xB 3 platform, which is a peptide-based technology, for the transport of therapeutic agents, in particular biological products, across the blood-brain barrier (BBB). It is focused on both orphan drug indications, including brain cancers, and rare genetic neurodegenerative diseases and neuroinflammatory conditions. The Company is also focused on its Epidermal Growth Factor (EGF) platform for treating rare and orphan neurodegenerative and neuroinflammatory disorders. EGF is a protein that stimulates cell growth and differentiation, notably for myelin producing cells. Its development programs include xB3-001: Brain Metastases, xB3-002: Glioblastoma and xB3-007: Neurodegenerative Disease.


TSXV:BTI.H - Post by User

Comment by prophetoffactzon Feb 25, 2023 9:41am
114 Views
Post# 35305056

RE:RE:Protalix

RE:RE:Protalix"Unfortunately, Bioasis has already been paid by Chiesi for its LSDs. Future developmental, regulatory and commercial milestone payments are set at an average of $34.5 million per LSD. There is also a royalty that can't come into play for many years."

If the Chiesi/xB3 deal is worth C$500 million in upfront, potential milestones, and potential royalty payments in the future under riskless conditions it is closer to realizing that value now with the positive CHMP recommendation for Fabry. I understand the correlation between a positive CHMP opinion and ultimate European and FDA approval is very high. Chiesi also just received FDA approval for another ERT. How much work has Chiesi done towards an IND to further de-risk the xB3 deal over the last 2 1/2 years? How much closer to realizing the $500 million is the deal now? The deal could be significantly more valuable upfront right now. Protalix has doubled in price in the last four months alone. How much value is still left outside of the Xoma deal for BTI to work with in deal making? Midatech was talking up the partnerships and the value of the existing xB3 deals.

Chiesi is also now on a more certain path to becoming a strategic player in Lysosomal Storage. Lysosomal Storage is a key strategic focus. xB3 has become a more strategic asset now that Chiesi's path is more certain and it will be willing to pay for a second xB3 deal accordingly, upfront. Denali has also further strengthened the validation for ERT delivery to the brain recently and BTI has Hunter data expected in Q2. 

There is a lot of potential upfront value BTI may be able to use in deal making right now. On the outside we can only guess. The outcome could be bankruptcy to significant surprise. Also, the J&J multi-product option appears to have progressed.
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