RE:TIGIT class of checkpoint inhibitors fails with Keytruda In March last year Roche’s trial with their anti-TIGIT drug tiragolumab in small cell lung cancer (SCLC) also ended in failure.
Adding tiragolumab to checkpoint inhibitor Tecentriq and chemotherapy failed to improve progression-free survival in the study of 490 people undergoing first-line treatment for SCLC, causing the trial to miss one of its co-primary endpoints.
https://www.fiercebiotech.com/biotech/roches-lung-cancer-gamble-flames-out-tigit-digits-come-short-phase-3