Biomedical Optics Spie Presentation27 June 2023 • 8:45 AM - 9:00 AM CEST Development of a protocol for whole-lung in vivo lung perfusion assisted photodynamic therapy for the treatment of lung metastases Authors: Khaled Ramadan (presenter), Tina Saeidi, Marcelo Cypel, Lothar Lilge
Abstract
Significance: Isolated lung metastases remain a clinical challenge with standard-of-care treatments. In Vivo Lung Perfusion, a novel technique, replaces blood with acellular perfusate to allow greater light penetration for photodynamic treatments. The purpose of this study was to develop a whole-lung personalized photodynamic protocol. Results: A porcine model was used, whereby pigs underwent a simplified lung perfusion procedure, followed by photodynamic therapy with 5-ALA or chlorin e6. Dose volume histograms demonstrated homogenous light delivery. The photodynamic threshold and therapeutic windows of 5-ALA and chlorin e6 were demonstrated. Conclusions: This study demonstrated the safety and feasibility of a whole-lung perfusion assisted photodynamic therapy protocol, with in silico dosimetry planning.