RE:crosstalk between senescent cells and CD8 T cell-dependent aONCY's pelareorep (reovirus) capabiltiy of remodeling an immunosuppressive / hypoxic tumor microenvironment (TME) results in the ability upregulating of turning "cold" tumors into "hot" tumors through innate and adaptive immune responses to treat a variety of cancers, and overcoming the issue of T-Cell exhaustion through clonal proliferation of T-cell and the prevention of MHC-1 loss through the expanded expression of MHC-1 ligand (Murphy et al., 2019), leading to the increase of CD8+ T-cells, along with dendritic and NK immune cells involved in the "cross priming" in the TME.
Cross priming is a process which dendritic cells activate CD8+ T cells by cross presenting exogenous antigens, and plays a critical role in generating anti-tumor CD8+ T-cell immunity, which is an accomplishment that ONCY's oncolytic virus pelareorep has demonstrated in ONCY's Aware-1, Bracelet-1 and Goblet-1 Phase 2 clinical trials. .