RE:RE:RE:RE:RE:Thoughts on AACR Posters -- overall, very good DELTAs.If TH1902 indeed stop working after one or two weeks I would guess it is not because of lack of only internalizations as they did have off targeted delivery resulting in side effects so I would think the drug internalizes in both healthy and cancerous cells under constant pressure will eventually develop “acquired resistance” to the cytotoxic agents due to mutations among others. During the trial the cycles were on constant basis every 3 weeks followed by similar time period for their analysis (rest time), however they did mention in previous CPs other alternatives such as weekly and intermittent dosing. The idea about on/off or high/low dosing is the adaptive dosing may interrupt the growth of drug-dependent resistant cancerous cells which seems be an alternative route of dosing schedule for traditional chemo and I can’t see why it cannot be applied to targeted therapy. We will see whether the new dosing strategies after the restart would consider any of these.