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Theralase Technologies Inc. V.TLT

Alternate Symbol(s):  TLTFF

Theralase Technologies Inc. is a Canada-based clinical-stage pharmaceutical company. The Company is engaged in the research and development of light activated compounds and their associated drug formulations. The Company operates through two divisions: Anti-Cancer Therapy (ACT) and Cool Laser Therapy (CLT). The Anti-Cancer Therapy division develops patented, and patent pending drugs, called Photo Dynamic Compounds (PDCs) and activates them with patent pending laser technology to destroy specifically targeted cancers, bacteria and viruses. The CLT division is responsible for the Company’s medical laser business. The Cool Laser Therapy division designs, develops, manufactures and markets super-pulsed laser technology indicated for the healing of chronic knee pain. The technology has been used off-label for healing numerous nerve, muscle and joint conditions. The Company develops products both internally and using the assistance of specialist external resources.


TSXV:TLT - Post by User

Comment by NotinKansason May 01, 2023 12:55am
172 Views
Post# 35422199

RE:RE:RE:72% CR at any point in time.

RE:RE:RE:72% CR at any point in time.Hi Wildbird, no offense, I appreciate your attempts to help us arrive at a better understanding of the numbers, but I don’t pretend or mislead. To further explain my comment: the ordering principle in these swimmer plots is the number of assessments patients have received: those who received 5 assessments appear on top, those who received only one, appear at the bottom. In our case we have 10 patients who received only their 90 days assessment and who apparently (if the key to the plot is accurate) will not receive further treatment/assessment. Nine out of these 10 are NR. They will be stuck at the bottom of the plot forever (or until they are officially removed from the study), and the same faith waits for any other patient that for whatever reason doesn’t move beyond their 90-days assessment. What we learn from the swimmer plots is that in this trial not everybody receives the two treatments and the full five assessments. For reasons unknown to us, some patients only make it to the 90-days assessment, others only to 180 days, and so on. We can also see that a patient is more likely to receive the maintenance treatment and follow-up assessments if they are CR or IR, and that that a patient is likely to receive no further assessment when they at some point become NR. There are exceptions (like the one you refer to, and also #34 who achieved CR at 90 and 180 days but apparently does not continue), but the tendency is clear: well-responding patients move up in the plot while non-responding patients remain stuck at the point of their last assessment meaning they will become overrepresented in the lower part of the plot, which also means that making comparisons between such plots is tricky business and needs to be done very carefully.
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