RE:RE:RE:RE:72% CR at any point in time.I agree that the 12 undertreated should be removed from the analysis, but they are not removed from the current data presentation at all. Not at 90 days and not at any of the other time points. From those 12, two made it CR all the way through to 450 days and one ended IR at 450 days (see MD&A of 28 April 2022). They are in the swimmers’ plot. The others will be there as well, up until the last assessment they received.
Key to understanding the plot is acknowledging that it shows only assessments that have actually taken place, not the number of patients that – timewise – have reached a certain stage. There are currently 31 (plus or minus 1) patients who have been long enough in the trial to have timewise qualified for their 450 days assessment. According to the plot, however, only 12 have actually received that assessment. The other 19 have not received it and, so it would seem, are also not going to get that assessment. We can only speculate about the reasons for that: trial protocol, patients stepping out voluntarily, or something else.
From a trial perspective there is also little point in continuing assessments once a patient is (still) NR at 270 days. They are very unlikely to change to IR or CR after that and therefore will not further contribute to Objective 1 or 2. You could say it’s economic.