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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Post by lonc17on May 28, 2023 8:53pm
380 Views
Post# 35468180

IND213

IND213

These results from Bracelet (yet to be updated to May but almost certain to be strong) go a very long way toward validating IND213.

The results from IND213 were very impressive but always in doubt due to an unfortunate fluke. There was a built in bias in the data due to the test group having favourable CELTIL scores vs the control goup. I bielieve the Ecog scores were also skewed in favour of the test goup. 

This was IMO the reason why ONC failed to secure partner or buyout and an immediate launch into P3.

But now we have Bracelet. Having two randomized trials showing statistical signifance in favour of Pelareorep is very impressive and gives a fresh look at IND213.  

Now when ONC says, "a near doubling of OS" it is much more convincing that this is due to treatment affect rather than a lucky roll of the dice (during randomization).

I say again that for those close to this story this week may be the best buying opporutnity in the past 20 years. 

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