RE:HG NMIBC & CIS HG NMIBC...?????wildbird1 wrote: In the last Swimmer Plot TLT said "Red Dot = HG NMIBC".
At the next AGM we should ask TLT to clarify if the red dot are true HG NMIBC or Non-Response patients.
If you google HG NMIBC & CIS HG NMIBC, you will realize that there is a huge difference between a HG NMIBC and a CIS HG NMIBC patient.
- A HG NMIBC patient is not in imminent danger of losing his(her) bladder, and can be treated with BCG.
-A CIS HG NMIBC patient is in imminent danger of losing his(her) bladder, and is untreatable( for now).
All TLT patients are CIS HG NMIBC, they are all in danger of losing their bladder.
Could it be possible that after TLT treatment these CIS HG NMIBC patients did reverse back to being simply a HG NMIBC patient(no CIS)?
A HG NMIBC patient is simply a patient that is not cured, but he is not in imminent danger of losing his bladder( unlike a CIS HG NMIBC patient).
Or could it be that the term HG NMIBC in the last Swimmer Plot is a typo error? It is the third Swimmer Plot were TLT use the term HG NMIBC(without CIS), there is a big chance that it is not a typo error.
In the last Swimmer Plot at 450 days...
25 patients are HG NMIBC( they still have their bladder) .
11 patients are CR.
1 patient is IR.
Total 37 patients.
Note: In the May 10,2023 PressRelease, TLT said" The goal of therapy in patients with BCG-Unresponsive NMIBC is to avoid cystectomy".
The reason TLT should clarify this situation is, if these patients are true HG NMIBC ( not Non Response patients) it does change the dynamic of a Big Pharma deal, a Big Pharma would have to pay very very big money for a treatment were 100% of patients treated still have their bladder at 450 days(and counting).
I was told that no patient had progression