RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:Very encouraging, but approval will take timeIt sounded somewhat along these lines from putting together a few of the answers they provided. I am sure there is way more science and nuance to understand it all and as that simple-minded layman, one question I would have is how long is the process for sort1 to internalize, cleave the linker inside cell, and re-externalize to surface of that cell?
This has been the slide they've used for over a year now. If it's seconds and not minutes or hours it would make a difference. If it recycles quicker than degradation, that would be helpful. I guess the rate of docetaxol being "hoovered" up and out by the kidneys would also be worth knowing as I assume not all docetaxol lands in a spot creating TSAEs and some just exits.
One last point on totally different topic that I recall hearing 3 times from Dr. Meric's mouth -- having a tubulin fighting drug for this stage of cancer appears to be both novel and would make it very commercial.