Ceapro Inc V.CZO

Wound healing

[prophetoffactz]

It has been said that athelerosclerosis is an unclosed wound. Could CZO help heal it?

Macrophages also play an important role in wound healing and PGX has very interesting results with PGX and macrophages.

"Macrophages are critically involved in wound healing, from dampening inflammation to clearing cell debris and coordinating tissue repair. Within the wound, the complexity of macrophage function is increasingly recognized, with adverse outcomes when macrophages are inappropriately activated, such as in fibrosis or chronic non-healing wounds." Management of hard-to-heal wounds arising as a result of surgical oncology treatment- usage of the modern wound dressings - PubMed (nih.gov) 

As for wound healing topical and systemic treatments have been used together and CZO has now investigated both. 

CZO news release:

"These results will support additional claims for these products currently used in well-known cosmetic formulations while opening doors for Ceapro in the large and well-established wound healing and tissue regeneration markets, further positioning Ceapro in dermatology."

------

6. Conclusions

In vivo studies and human clinical trials have provided compelling evidence that β-glucan preparations including hydrogels and nanofibers with incorporated β-glucan molecules promote moist wound healing and repair mainly due to the activation of the immune and cutaneous cells. β-glucans can induce the proliferation and migration of keratinocytes and fibroblasts through specific receptors such as Dectin-1, CR3 or TLRs. The direct antibacterial properties of β-glucans remain controversial as they have not been demonstrated in vivo. However, it was proposed that activation of wound macrophages and antigen-presenting cells by β-glucan represents a potential mechanism in eradicating bacterial load from chronic wounds.

Besides therapeutic benefits, treating chronic wounds with β-glucan hydrogels can help with reducing healing time and the total costs per treatment, but additional human clinical studies are needed to prove the efficacy of β-glucan-based wound dressings in treating a broad spectrum of chronic wounds and burns.
Molecules | Free Full-Text | β-Glucans: Multi-Functional Modulator of Wound Healing (mdpi.com)