AA and mBCIf I recall correctly, paxlitaxol is now generic, or at least under a sowewhat different patent regime than initially.
If that is the case, I would think there are not many obstacles to ONCY applying directly to the FDA for the pax'pelo combo for mBC for accelerated approval.
Hence that might be the most direct path to AA. Or we could apply for AA for pela on its own, which has virtually the same pfs results as Trodelvey, an ADC that is beign prasied on the NYT front page today. We have far less side effects than Tro and would likely cost a lot less also.
With the panc results, the combo is with Tecentriq which Roche owns, so it seems that it would be harder if not impossible for us to apply to the FDA for AA without Roche.