RE:What have we got here? ONCY's pelareorep activates the interferon (IFN) signalling pathway which stimulates the innate and adaptive immune system where gamma-delta (γδ) T cells, play a critical role in filling the gap needed for adaptive immune cells maturation, linking the innate and adaptive immunity together.
The AWARE-1 study results presented at SABC 2022 on December 07, 2022 demonstrated that pelareorep activated the IFN signalling pathway and "primes" the tumor in advance of immune checkpoint inhibition. (see below)
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