Been getting a few requests on why I think CRC and pelareoreWill Pelareorep get a P3 in Colorectal cancer.
Here's a few of my links to support that theory.
"Oncolytic reovirus (pelareorep) is a non-enveloped dsRNA virus that selectively lyses KRAS-mutated colorectal tumor cells. KRAS mutations are prevalent in 40-45% of colorectal cancer (CRC) patients, and treatment options are limited." JULY 2022.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334725/
Immune characterization of metastatic colorectal cancer patients post reovirus. 2020.
administrationhttps://pubmed.ncbi.nlm.nih.gov/32552875/
Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan. 2014.
https://pubmed.ncbi.nlm.nih.gov/24798549/
Elucidation of Pelareorep Pharmacodynamics in A Phase I Trial in Patients with KRAS-Mutated Colorectal Cancer 2020.
https://pubmed.ncbi.nlm.nih.gov/32156785/
Oncolytic Reovirus (pelareorep) Induces Autophagy in KRAS-mutated Colorectal Cancer. 2021.
https://aacrjournals.org/clincancerres/article/27/3/865/83394/Oncolytic-Reovirus-pelareorep-Induces-Autophagy-in
April 2023 Colorectal and Stem cells.
https://www.sciencedirect.com/science/article/pii/S0753332223001610
Reovirus Colorectal and Stem cells
https://www.sciencedirect.com/science/article/abs/pii/S0006295221002574