Theralase Technologies Inc. V.TLT

RE:Sonodynamic Therapy Explained

[ScienceFirst]

Nice posts Pandora and Made2last on SonoTherapy that TLT is aiming for, in order to treat deep-seated tumors with our metal complex PDCs.  

• SONODYNAMIC THERAPY USING SONODYNAMICALLY ACTIVATED COORDINATION COMPLEXES OF TRANSITION METALS AS SENSITIZING AGENTS

  Publication number: 20220296709

  Abstract: A method for destroying cells and/or microorganisms in an organism includes the following steps: (a) administering to the organism a composition including a sonosensitizing compound containing at least one transition metal with three bidentate ligands; and (b) exposing the sonosensitizing compound in the organism to ultrasound, wherein the ultrasound is effective to activate the sonosensitizing compound to destroy at least one of the cells and the microorganisms in the organism. The ultrasound is preferably used in conjunction with electromagnetic therapies comprising photodynamic therapy, low-level laser therapy, and radiation therapy. The ultrasound is preferably administered at a duty cycle in the range from 5% to 95% at a power density of 10 W/cm2 and a frequency in the range from 10 Hz to 10 MHz.

  Type: Application

  Filed: March 4, 2021

  Publication date: September 22, 2022

  Inventors: Arkady Mandel, Roger Dumoulin-White

So, after PDT, that would be our 2nd way of taken advantage of the amazing potency of our PDCs to destroy tumors, no matter where they are in the body, for example in deep-seated tissues/organs.


Take a look at this 2022 article too:

https://pubmed.ncbi.nlm.nih.gov/34878223/
 

Sonodynamic Therapy with Metal Complexes: A New Promise in Cancer Therapy

Ashish Kumar Yadav et al. ChemMedChem. 2022

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Abstract

In recent years, to overcome the problem of low tissue penetration power of light in photodynamic therapy (PDT), sonodynamic therapy (SDT) with ultrasound (US) as the drug stimulus has emerged as a potential alternative to PDT. The significantly higher tissue penetration capacity of US is reported to allow the treatment of deep-seated tumours. In general, organic molecules and nanomaterials dominate as the sonosensitizers in this area of research, and the potential of metal complexes in SDT is not yet well explored. In this highlight, we have summarized two recent literature reports in which researchers have explored the efficiency of metal complexes as sonosensitizers for the first time. These reports indicate the high potential of metal complexes in SDT.

Keywords: Metal complex; Singlet oxygen; Sono-cytotoxicity; Sonodynamic therapy; Ultrasound.