Oncolytics Biotech Inc T.ONC

RE:Pfizer's CD3 bispecific to compete with CAR -T therapy

[Noteable]

Pfizer's elranatamab, is an investigational B-cell maturation antigen (BCMA) CD3-targeted bispecific antibody (BsAb), for the treatment of patients with relapsed or refractory multiple myeloma (RRMM), a liquid (blood) cancer.

ONCY's involvement with Dr. Richard Vile of the Mayo Clinic involves the use of CAR-T + pelareorep in solid tumors, where applications are significantly greater than anything in liquid cancers.

This notwithstanding:

"Findings presented at the 2023 ASCO Annual Meeting showed that at a median follow-up of 11.3 months (range, 0.3-32.3), patients treated with elranatamab after any prior BCMA-directed therapy (n = 87) achieved an overall response rate (ORR) of 46% (95% CI, 35.2%-57.0%), including a stringent complete response (sCR) rate of 4.6%, a complete response (CR) rate of 13.8%, a very good partial response (VGPR) rate of 24.1%, and a partial response (PR) rate of 3.4%). Among patients who experienced a response (n = 40), the median time to response was 1.7 months (range, 0.3-9.3). 

Among patients who received a prior BCMA-directed antibody-drug conjugate (ADC; n = 59), the ORR was 42.4% with sCR, CR, VGPR, and PR rates of 5.1%, 13.6%, 20.3%, and 3.4%, respectively. Those who had prior treatment with a BCMA-directed CAR T-cell therapy (n = 36) achieved an ORR of 52.8%, including sCR, CR, VGPR, and PR rates of 2.8%, 16.7%, 27.8%, and 5.6%, respectively. Notably, 8 patients received prior treatment with both a BCMA-directed ADC and CAR T-cell therapy."

https://www.onclive.com/view/elranatamab-elicits-responses-in-relapsed-refractory-myeloma-after-prior-bcma-directed-therapy