Could CBD and THC be Useful for Tourette’s Syndrome? Medical Cannabis and Tourette’s Syndrome
Some compounds derived from the cannabis plant – namely the cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD) – have been suggested as an area to explore within Tourette’s Syndrome research. These cannabinoids are known to modulate the endocannabinoid system (ECS) – a receptor system that plays a role in a number of cognitive and physiological processes.
Of particular interest in this setting is the cannabinoid CB1 receptor (CB1R) which is densely concentrated in the basal ganglia, believed to be the pathobiological nexus of Tourette’s Syndrome. Stimulation of the CB1R has been found to provide retrograde inhibition of excitatory synaptic activity. Furthermore, uncontrolled observational studies have highlighted an association between cannabis use and change in tic severity. These include a number of placebo-controlled studies that assessed the effects of various THC formulations and a single case study of nabiximols.
https://www.sapphireclinics.com/could-cbd-and-thc-be-useful-for-tourettes-syndrome/