RE:RE:RE:My calculations add up to more than current sp !Roswell Park uses PDCs off label for various forms of cancer.
https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://www.roswellpark.org/cancer-care/treatments/photodynamic-therapy/diseases-we-treat-pdt%23:~:text%3DRoswell%2520Park%2520physicians%2520sometimes%2520offer,be%2520effective%2520for%2520that%2520use.&ved=2ahUKEwio8bbM046BAxWqNzQIHSIdACQQFnoECA4QBQ&usg=AOvVaw3zSqymer3He65YxRnHQ4GU Off-label use
Off-label use of a drug means that the drug has been approved by the FDA for a specific disease or condition, but it is being prescribed for a different, unapproved use or condition. FDA regulations allow doctors to prescribe medications off-label, and sometimes the medications’ effectiveness for an off-label use can lead to FDA approval for that new use. For example, sildenafil (Viagra) was originally approved by the FDA to treat angina (chest pain caused by inadequate blood flow to the heart), but off-label use showed that it could also be effective in treating erectile dysfunction.
Roswell Park physicians sometimes offer patients off-label use of Photofrin, one type of photosensitizer used in PDT, for treatment of such diseases as oral cancer. While Photofrin is not FDA-approved for oral cancer, is has been shown to be effective for that use.
Roswell Park treats these diseases with PDT off-label:
Gynecologic malignancies
Gynecologic tumors often occur in areas that can be accessed easily by the red light used in PDT. PDT with Photofrin® may be effective in certain cases for treating tumors of the vagina, vulva and cervix. In recurrent tumors, this therapy has sometimes resulted in long-lasting results.
Head & neck cancer and dysplasia
PDT can be used effectively for cancers or dysplasias (areas with abnormal cells) in the mouth, including the tongue, cheek, floor of the mouth, roof of the mouth and other areas. The majority of procedures are done on an outpatient basis.
Skin cancers
Skin cancers are treated using PDT in conjunction with the Dermatology Department at Roswell Park. These types of skin cancer may be treated effectively with PDT:
- Basal cell carcinoma, the most common type of skin cancer
- Bowen's disease
- Nevoid basal cell carcinoma syndrome (NBCCS)
A menu of photosensitizers
We select from a menu of different types of photosensitizers available from pharmaceutical companies around the world, based on your specific needs, including age and overall health.
Oden6570 wrote: 99942Apophis wrote: Oden6570 wrote: Intellectual Property 46 issued patents for PDC and laser technology in the United States, Canada and internationally1 Composition of matter patent expires in US in 2033 (Potentially 2038 with extension)
23 patents pending Theralase-Corporate-Presentation-05-18-2023.pdf
Good read Oden6570, my concern with overall numbers quoted in this report didn't differentiate out of their North American (91,000) or World (573,000) numbers that 75% are NMIBC and 25% are MIBC. Am I to assume that perhaps MIBC will also be treatable by Theralase?
Someone mentioned that once approved Urologists could use Ruvidar for non label use ! I assume this means it is up to the Doc when to use. I am not sure however if I am accurate in this assumption. Perhaps others may shed light on this issue.