RE:RE:RE:RE:RE:RE:RE:RE:RE:Well?Thanks. So we share one active drug because in my case capecitabine is a prodrug of 5-FU (5-fluorouracil). The prodrug allows to take it orally, contrary to 5-FU that needs to be taken by IV because of its poor solubility in water, like docetaxel. But after it's in the body, two enzymatic cleavages of capecitabine allows to transform it into 5-FU in the cancer cells. Also you are right, Avastin is not a drug usually used to treat neuroendocrine cancers.
PWIB123 wrote: jfm1330 - Here's a copy of dad's current regiment. I don't have access to what he was prescribed the first time, but my understanding is that it included Avastin and two supplemental non-chemo drugs that had names too long for me to write down. What I remember about the two non-chemo drugs is that the Dr. said they've now learned that they have some nasty side effects and don't feel any real benefit to the cancer itself. So, they are not including those this time. My dad nearly experienced kidney failure last year due to Avastin and was going to have to go on dialysis, so he's needing to avoid anything that's too harsh on the kidneys. Good news is that when he came off of Avastin, his kidneys nearly completely recovered.
Regimen Name: FOLFOX5 (5-Fluorouracil, Oxaliplatin)
Chemotherapy:
1. Oxaliplatin 85 mg IV over 2 hours on day 1
2. Leucovorin and bolus fluorouracil: OMIT for tolerability
3. 5-Fluorouracil 2400 mg IV continuous infusion over 46 hours starting on day 1
Frequency: Each cycle = 14 days