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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Healthcare Biotechnology
Oncolytics Biotech Inc. is a biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to phase 3 licensure-enabling studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > Roche CD47 antibody start-up gives up-lays off all employees
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Comment by Noteableon Oct 05, 2023 3:13pm
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Post# 35671723

RE:RE:RE:Roche CD47 antibody start-up gives up-lays off all employees

RE:RE:RE:Roche CD47 antibody start-up gives up-lays off all employeesOctober 05, 2023 - US clinical-stage immuno-oncology company ALX Oncology Holdings (Nasdaq: ALXO) saw its shares rocket 56% to $7.51 yesterday, as it announced positive clinical results for its lead asset after a previous disappointment. 

ALX announced positive prespecified interim Phase II data from its ASPEN-06 clinical trial, a randomized multi-center international study evaluating evorpacept, the company’s CD47 blocking therapeutic, in combination with trastuzumab, Cyramza (ramucirumab) and paclitaxel for the treatment of patients with HER2-positive gastric/gastroesophageal junction (GEJ) cancer. 

The interim analysis revealed that patients receiving evorpacept in combination with other cancer drugs had a 52% overall response rate. This was a significant improvement compared to the 22% response rate observed in the control group, which did not receive evorpacept.  

In addition, ASPEN-06 is the first global randomized study in HER2-positive gastric cancer where prior Keytruda (pembrolizumab) and Enhertu were allowed. 

https://www.thepharmaletter.com/article/alx-oncology-soars-on-phase-ii-results-of-evorpacept-in-gastric-cancer


 

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