Outstanding Encouraging Results...Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Andres Alguacil, Franco Scalambra, Antonio Romerosa, Andreia Bento-Oliveira, Fernanda Marques, Ines Maximiano, Rodrigo F. M. de Almeida, Ana Isabel Tomaz, and Andreia Valente
Published 28 Sept 2023
...Research efforts targeted to obtain alternatives to Pt(II) compounds have led to the development of new complexes containing metals that adopt different coordination geometries concerning the strictly square planar of Pt(II) and Pd(II). Among the transition metals that meet this requirement, ruthenium is one of the most promising [10–12]. Several ruthenium-based compounds have shown outstanding encouraging results such as Ru(III) complexes KP1019 (replaced by NKP1339/IT-139) and NAMI-A, which entered phases I and II of clinical trials, respectively [12]. Other examples are the Ru(II) complex TLD1433, which was evaluated in phase II [13, 14], and the compounds of the family of RAPTAs, which were tested in preclinical trials [15–17]. This latter group of complexes exhibits a Ru-(η6-arene) scaffold and 1,3,5-triaza-7-phosphaadamantane (PTA, 1) together with two chlorides (Figure 1) [18]. The combination of ligands and their arrangement around the metal provides a stable platform with adequate hydrosolubility, stabilizing the Ru(II) oxidation state [19]....