RE:RE:RE:RE:RE:RE:RE:RE:RE:ONCY pelareorep demonstrates 69% ORR in pancreatic cancerT cell receptor sequencing (TCR-seq) in ONCYs GOBLET Phase 1/2 clinical trial in metastatic pancreatic cancer showed an expansion of new and pre-existing T-cell clones.
TCR sequencing is a technique that measures the diversity and clonality of T cell receptors (TCRs) in a sample. TCRs are molecules on the surface of T cells that recognize and bind to antigens, which are foreign substances that trigger an immune response.
TCR sequencing can provide information about the immune status and activity of a patient, especially in the context of cancer immunotherapy, and therefore is considered a predictive biomarker of positive treatment outcome.